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Though specific interplay research were not conducted for all medicinal products, population pharmacokinetic evaluation showed no impact of concomitant treatment on sildenafil pharmacokinetics when grouped as CYP2C9 inhibitors (corresponding to tolbutamide, warfarin, phenytoin), CYP2D6 inhibitors (such female viagra as selective serotonin reuptake inhibitors, tricyclic antidepressants), thiazide and associated diuretics, loop and potassium sparing diuretics, angiotensin changing enzyme inhibitors, calcium channel blockers, beta-adrenoreceptor antagonists or inducers of CYP450 metabolism (equivalent to rifampicin, barbiturates).
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